Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Identifieur interne : 000440 ( Main/Exploration ); précédent : 000439; suivant : 000441Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Auteurs : Fei Zhang ; Yuan Zhang ; Ting Yang ; Ze-Qing Ye ; Jing Tian ; Hai-Rong Fang ; Juan-Juan Han ; Zhe-Zhi Wang ; Xing LiSource :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Scopoletin, a phenolic coumarin derived from many medical or edible plants, is involved in various pharmacological functions. In the present study, we showed that Scopoletin effectively ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through novel regulatory mechanisms involving inhibition of NF-κB activity in dendritic cells (DCs). Scopoletin treatment significantly improved the severity of the disease and prominently decreased inflammation and demyelination of central nervous system (CNS) in EAE mice. Disease alleviation correlated with the downregulation of major histocompatibility complex (MHC) class II, CD80 and CD86, expressed on DCs of CNS or spleens, and the infiltration and polarization of encephalitogenic Th1/Th17 cells. Consistent with the
Url:
DOI: 10.3389/fphar.2019.00863
PubMed: 31427972
PubMed Central: 6688631
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling</title>
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<author><name sortKey="Yang, Ting" sort="Yang, Ting" uniqKey="Yang T" first="Ting" last="Yang">Ting Yang</name>
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<author><name sortKey="Ye, Ze Qing" sort="Ye, Ze Qing" uniqKey="Ye Z" first="Ze-Qing" last="Ye">Ze-Qing Ye</name>
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<author><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name>
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<author><name sortKey="Fang, Hai Rong" sort="Fang, Hai Rong" uniqKey="Fang H" first="Hai-Rong" last="Fang">Hai-Rong Fang</name>
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<author><name sortKey="Han, Juan Juan" sort="Han, Juan Juan" uniqKey="Han J" first="Juan-Juan" last="Han">Juan-Juan Han</name>
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<author><name sortKey="Wang, Zhe Zhi" sort="Wang, Zhe Zhi" uniqKey="Wang Z" first="Zhe-Zhi" last="Wang">Zhe-Zhi Wang</name>
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<front><div type="abstract" xml:lang="en"><p>Scopoletin, a phenolic coumarin derived from many medical or edible plants, is involved in various pharmacological functions. In the present study, we showed that Scopoletin effectively ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through novel regulatory mechanisms involving inhibition of NF-κB activity in dendritic cells (DCs). Scopoletin treatment significantly improved the severity of the disease and prominently decreased inflammation and demyelination of central nervous system (CNS) in EAE mice. Disease alleviation correlated with the downregulation of major histocompatibility complex (MHC) class II, CD80 and CD86, expressed on DCs of CNS or spleens, and the infiltration and polarization of encephalitogenic Th1/Th17 cells. Consistent with the <italic>in vivo</italic>
data, Scopoletin-treated, bone marrow-derived dendritic cells (BM-DCs) exhibited reduced expression of MHC class II and costimulatory molecules (e.g., CD80 and CD86) and reduced NF-κB phosphorylation. These findings, for the first time, demonstrated the ability of Scopoletin to impair DC activation, downregulating pathogenic Th1/Th17 inflammatory cell responses and, eventually, reducing EAE severity. Our study demonstrates new evidence that natural products derived from medical or edible plants, such as Scopoletin, will be valuable in developing a novel therapeutic agent for MS in the future.</p>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Fang, Hai Rong" sort="Fang, Hai Rong" uniqKey="Fang H" first="Hai-Rong" last="Fang">Hai-Rong Fang</name>
<name sortKey="Han, Juan Juan" sort="Han, Juan Juan" uniqKey="Han J" first="Juan-Juan" last="Han">Juan-Juan Han</name>
<name sortKey="Li, Xing" sort="Li, Xing" uniqKey="Li X" first="Xing" last="Li">Xing Li</name>
<name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name>
<name sortKey="Wang, Zhe Zhi" sort="Wang, Zhe Zhi" uniqKey="Wang Z" first="Zhe-Zhi" last="Wang">Zhe-Zhi Wang</name>
<name sortKey="Yang, Ting" sort="Yang, Ting" uniqKey="Yang T" first="Ting" last="Yang">Ting Yang</name>
<name sortKey="Ye, Ze Qing" sort="Ye, Ze Qing" uniqKey="Ye Z" first="Ze-Qing" last="Ye">Ze-Qing Ye</name>
<name sortKey="Zhang, Fei" sort="Zhang, Fei" uniqKey="Zhang F" first="Fei" last="Zhang">Fei Zhang</name>
<name sortKey="Zhang, Yuan" sort="Zhang, Yuan" uniqKey="Zhang Y" first="Yuan" last="Zhang">Yuan Zhang</name>
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</affiliations>
</record>
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